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Nucleus-targeted Dmp1 transgene fails to rescue dental defects in Dmp1 null mice

Dentin matrix protein 1 (DMP1) is essential to odontogenesis. Its mutations in human subjects lead to dental problems such as dental deformities, hypomineralization and periodontal impairment. Primarily, DMP1 is considered as an extracellular matrix protein that promotes hydroxyapatite formation and...

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Detalhes bibliográficos
Main Authors: Lin, Shu-Xian, Zhang, Qi, Zhang, Hua, Yan, Kevin, Ward, Leanne, Lu, Yong-Bo, Feng, Jian-Quan
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2014
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4170153/
https://ncbi.nlm.nih.gov/pubmed/25105818
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ijos.2014.44
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