Intracellular alpha-synuclein affects early maturation of primary oligodendrocyte progenitor cells

Myelin loss is a widespread neuropathological hallmark of the atypical parkinsonian disorder multiple system atrophy (MSA). On a cellular level, MSA is characterized by alpha-synuclein (aSyn)-positive glial cytoplasmic inclusions (GCIs) within mature oligodendrocytes leading to demyelination as well...

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Main Authors: Ettle, Benjamin, Reiprich, Simone, Deusser, Janina, Schlachetzki, Johannes C.M., Xiang, Wei, Prots, Iryna, Masliah, Eliezer, Winner, Beate, Wegner, Michael, Winkler, Jürgen
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4170075/
https://ncbi.nlm.nih.gov/pubmed/25019582
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.mcn.2014.06.012
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