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Activation of Pattern Recognition Receptors Upregulates Metallothioneins, Thereby Increasing Intracellular Accumulation of Zinc, Autophagy, and Bacterial Clearance by Macrophages

BACKGROUND & AIMS: Continuous stimulation of pattern recognition receptors (PRRs), including nucleotide-binding oligomerization domain-2 (NOD2) (variants in NOD2 have been associated with Crohn's disease), alters the phenotype of myeloid-derived cells, reducing production of inflammatory cy...

詳細記述

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書誌詳細
主要な著者: Lahiri, Amit, Abraham, Clara
フォーマット: Artigo
言語:Inglês
出版事項: 2014
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC4170054/
https://ncbi.nlm.nih.gov/pubmed/24960189
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1053/j.gastro.2014.06.024
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