Inhibition of TYK2 and JAK1 Ameliorates Imiquimod-Induced Psoriasis-like Dermatitis by Inhibiting IL-22 and the IL-23/IL-17 axis

Psoriasis is a chronic autoimmune disease affecting the skin and characterized by aberrant keratinocyte proliferation and function. Immune cells infiltrate the skin and release proinflammatory cytokines that play important roles in psoriasis. The Th17 network, including IL-23 and IL-22, has recently...

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Detalhes bibliográficos
Main Authors: Works, Melissa G., Yin, Fangfang, Yin, Catherine C., Yiu, Ying, Shew, Kenneth, Tran, Thanh-Thuy, Dunlap, Nahoko, Lam, Jennifer, Mitchell, Tim, Reader, John, Stein, Paul L., D’Andrea, Annalisa
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4170002/
https://ncbi.nlm.nih.gov/pubmed/25156366
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1400205
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