Human Metapneumovirus Inhibits IFN-β Signaling by Downregulating Jak1 and Tyk2 Cellular Levels

Human metapneumovirus (hMPV), a leading cause of respiratory tract infections in infants, inhibits type I interferon (IFN) signaling by an unidentified mechanism. In this study, we showed that infection of airway epithelial cells with hMPV decreased cellular level of Janus tyrosine kinase (Jak1) and...

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Hauptverfasser: Ren, Junping, Kolli, Deepthi, Liu, Tianshuang, Xu, Renling, Garofalo, Roberto P., Casola, Antonella, Bao, Xiaoyong
Format: Artigo
Sprache:Inglês
Veröffentlicht: Public Library of Science 2011
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3176284/
https://ncbi.nlm.nih.gov/pubmed/21949722
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0024496
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