No Beneficial Effect of General and Specific Anti-Inflammatory Therapies on Aortic Dilatation in Marfan Mice

AIMS: Patients with Marfan syndrome have an increased risk of life-threatening aortic complications, mostly preceded by aortic dilatation. In the FBN1 (C1039G/+) Marfan mouse model, losartan decreases aortic root dilatation. We recently confirmed this beneficial effect of losartan in adult patients...

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Bibliographic Details
Main Authors: Franken, Romy, Hibender, Stijntje, den Hartog, Alexander W., Radonic, Teodora, de Vries, Carlie J. M., Zwinderman, Aeilko H., Groenink, Maarten, Mulder, Barbara J. M., de Waard, Vivian
Format: Artigo
Language:Inglês
Published: Public Library of Science 2014
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4169510/
https://ncbi.nlm.nih.gov/pubmed/25238161
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0107221
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