A fully synthetic human Fab antibody library based on fixed VH/VL framework pairings with favorable biophysical properties

This report describes the design, generation and testing of Ylanthia, a fully synthetic human Fab antibody library with 1.3E+11 clones. Ylanthia comprises 36 fixed immunoglobulin (Ig) variable heavy (VH)/variable light (VL) chain pairs, which cover a broad range of canonical complementarity-determin...

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Detalhes bibliográficos
Main Authors: Tiller, Thomas, Schuster, Ingrid, Deppe, Dorothée, Siegers, Katja, Strohner, Ralf, Herrmann, Tanja, Berenguer, Marion, Poujol, Dominique, Stehle, Jennifer, Stark, Yvonne, Heßling, Martin, Daubert, Daniela, Felderer, Karin, Kaden, Stefan, Kölln, Johanna, Enzelberger, Markus, Urlinger, Stefanie
Formato: Artigo
Idioma:Inglês
Publicado em: Landes Bioscience 2013
Assuntos:
Report
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4169037/
https://ncbi.nlm.nih.gov/pubmed/23571156
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/mabs.24218
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