Removal of a C-terminal serine residue proximal to the inter-chain disulfide bond of a human IgG1 lambda light chain mediates enhanced antibody stability and antibody dependent cell-mediated cytotoxicity

Optimization of biophysical properties is a critical success factor for the developability of monoclonal antibodies with potential therapeutic applications. The inter-domain disulfide bond between light chain (Lc) and heavy chain (Hc) in human IgG1 lends structural support for antibody scaffold stab...

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Autors principals: Shen, Yang, Zeng, Lin, Zhu, Aiping, Blanc, Tim, Patel, Dipa, Pennello, Anthony, Bari, Amtul, Ng, Stanley, Persaud, Kris, Kang, Yun (Kenneth), Balderes, Paul, Surguladze, David, Hindi, Sagit, Zhou, Qinwei, Ludwig, Dale L., Snavely, Marshall
Format: Artigo
Idioma:Inglês
Publicat: Landes Bioscience 2013
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4169035/
https://ncbi.nlm.nih.gov/pubmed/23567210
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/mabs.24291
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