Immune suppression in cynomolgus monkeys by XPro9523: An improved CTLA4-Ig fusion with enhanced binding to CD80, CD86 and neonatal Fc receptor FcRn

The CTLA4-Ig fusion proteins abatacept and belatacept are clinically proven immunosuppressants used for rheumatoid arthritis and renal transplant, respectively. Given that both biologics are typically administered chronically by infusion, a need exists for a next-generation CTLA4-Ig with more conven...

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Hlavní autoři: Bernett, Matthew J., Chu, Seung Y., Leung, Irene, Moore, Gregory L., Lee, Sung-Hyung, Pong, Erik, Chen, Hsing, Phung, Sheryl, Muchhal, Umesh S., Horton, Holly M., Lazar, Greg A., Desjarlais, John R, Szymkowski, David E.
Médium: Artigo
Jazyk:Inglês
Vydáno: Landes Bioscience 2013
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4169032/
https://ncbi.nlm.nih.gov/pubmed/23549103
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/mabs.23976
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