Genetic factors affecting gene transcription and catalytic activity of UDP-glucuronosyltransferases in human liver

The aim of this study was to discover cis- and trans-acting factors significantly affecting mRNA expression and catalytic activity of human hepatic UDP-glucuronosyltransferases (UGTs). Transcription levels of five major hepatic UGT1A (UGT1A1, UGT1A3, UGT1A4, UGT1A6 and UGT1A9) and five UGT2B (UGT2B4...

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Autors principals: Liu, Wanqing, Ramírez, Jacqueline, Gamazon, Eric R., Mirkov, Snezana, Chen, Peixian, Wu, Kehua, Sun, Chang, Cox, Nancy J., Cook, Edwin, Das, Soma, Ratain, Mark J.
Format: Artigo
Idioma:Inglês
Publicat: Oxford University Press 2014
Matèries:
Association Studies Articles
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4168829/
https://ncbi.nlm.nih.gov/pubmed/24879639
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/hmg/ddu268
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