First-in-Human Evaluation of a Hexon Chimeric Adenovirus Vector Expressing HIV-1 Env (IPCAVD 002)

Background. We report the first-in-human safety and immunogenicity assessment of a prototype hexon chimeric adenovirus (Ad) serotype 5 (Ad5) vector containing the hexon hypervariable regions of Ad serotype 48 (Ad48) and expressing human immunodeficiency virus (HIV) type 1 EnvA. Methods. Forty-eight...

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Main Authors: Baden, Lindsey R., Walsh, Stephen R., Seaman, Michael S., Johnson, Jennifer A., Tucker, Robert P., Kleinjan, Jane A., Gothing, Jon A., Engelson, Brian A., Carey, Brittany R., Oza, Avinash, Bajimaya, Shringkhala, Peter, Lauren, Bleckwehl, Chelsea, Abbink, Peter, Pau, Maria G., Weijtens, Mo, Kunchai, Meghan, Swann, Edith M., Wolff, Mark, Dolin, Raphael, Barouch, Dan H.
Formato: Artigo
Idioma:Inglês
Publicado: Oxford University Press 2014
Assuntos:
Major Articles and Brief Reports
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4168302/
https://ncbi.nlm.nih.gov/pubmed/24719474
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/infdis/jiu217
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