Safety and Pharmacokinetics of the Antisense Oligonucleotide (ASO) LY2181308 as a Single-Agent or in Combination with Idarubicin and Cytarabine in Patients with Refractory or Relapsed Acute Myeloid Leukemia (AML)

SUMMARY: Survivin is expressed in tumor cells, including acute myeloid leukemia (AML), regulates mitosis, and prevents tumor cell death. The antisense oligonucleotide sodium LY2181308 (LY2181308) inhibits survivin expression and may cause cell cycle arrest and restore apoptosis in AML. METHODS: In t...

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Detalhes bibliográficos
Main Authors: Erba, Harry P., Sayar, Hamid, Juckett, Mark, Lahn, Michael, Andre, Valerie, Callies, Sophie, Schmidt, Shelly, Kadam, Sunil, Brandt, John T., Van Bockstaele, Dirk, Andreeff, Michael
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4167763/
https://ncbi.nlm.nih.gov/pubmed/23397500
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s10637-013-9935-x
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