Sequential transcriptional changes dictate safe and effective antigen-specific immunotherapy

Antigen-specific immunotherapy combats autoimmunity or allergy by reinstating immunological tolerance to target antigens without compromising immune function. Optimization of dosing strategy is critical for effective modulation of pathogenic CD4(+) T-cell activity. Here we report that dose escalatio...

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Autors principals: Burton, Bronwen R., Britton, Graham J., Fang, Hai, Verhagen, Johan, Smithers, Ben, Sabatos-Peyton, Catherine A., Carney, Laura J., Gough, Julian, Strobel, Stephan, Wraith, David C.
Format: Artigo
Idioma:Inglês
Publicat: Nature Pub. Group 2014
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4167604/
https://ncbi.nlm.nih.gov/pubmed/25182274
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms5741
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