Progesterone and Estradiol Synergistically Promote the Lung Metastasis of Tuberin-Deficient Cells in a Preclinical Model of Lymphangioleiomyomatosis

Lymphangioleiomyomatosis (LAM) is a female-predominant lung disease that can lead to respiratory failure. LAM cells typically have inactivating tuberous sclerosis 2 (TSC2) mutations, leading to mTORC1 hyperactivation. The gender specificity of LAM suggests that female hormones contribute to disease...

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Bibliographic Details
Main Authors: Sun, Yang, Zhang, Erik, Lao, Taotao, Pereira, Ana M., Li, Chenggang, Xiong, Li, Morrison, Tasha, Haley, Kathleen J., Zhou, Xiaobo, Yu, Jane J.
Format: Artigo
Language:Inglês
Published: Springer US 2014
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Original Paper
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4167496/
https://ncbi.nlm.nih.gov/pubmed/25069840
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s12672-014-0192-z
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