Estrogen promotes the survival and pulmonary metastasis of tuberin-null cells

Lymphangioleiomyomatosis (LAM) is an often fatal disease primarily affecting young women in which tuberin (TSC2)-null cells metastasize to the lungs. The mechanisms underlying the striking female predominance of LAM are unknown. We report here that 17-β-estradiol (E(2)) causes a 3- to 5-fold increas...

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Detalhes bibliográficos
Main Authors: Yu, Jane J., Robb, Victoria A., Morrison, Tasha A., Ariazi, Eric A., Karbowniczek, Magdalena, Astrinidis, Aristotelis, Wang, Chunrong, Hernandez-Cuebas, Lisa, Seeholzer, Laura F., Nicolas, Emmanuelle, Hensley, Harvey, Jordan, V. Craig, Walker, Cheryl L., Henske, Elizabeth P.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2009
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2637277/
https://ncbi.nlm.nih.gov/pubmed/19202070
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0810790106
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