The evolutionarily conserved TSC/Rheb pathway activates Notch in tuberous sclerosis complex and Drosophila external sensory organ development

Mutations in either of the genes encoding the tuberous sclerosis complex (TSC), TSC1 and TSC2, result in a multisystem tumor disorder characterized by lesions with unusual lineage expression patterns. How these unusual cell-fate determination patterns are generated is unclear. We therefore investiga...

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Detalhes bibliográficos
Main Authors: Karbowniczek, Magdalena, Zitserman, Diana, Khabibullin, Damir, Hartman, Tiffiney, Yu, Jane, Morrison, Tasha, Nicolas, Emmanuelle, Squillace, Rachel, Roegiers, Fabrice, Henske, Elizabeth Petri
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2009
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2798691/
https://ncbi.nlm.nih.gov/pubmed/20038815
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI40221
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