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Interictal spikes precede ictal discharges in an organotypic hippocampal slice culture model of epileptogenesis

In organotypic hippocampal slice cultures, principal neurons form aberrant excitatory connections with other principal cells in response to slicing-induced deafferentation, similar to mechanisms underlying epileptogenesis in post-traumatic epilepsy. To investigate the consequences of this synaptogen...

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Autori principali: Dyhrfjeld-Johnsen, J., Berdichevsky, Y., Swiercz, W., Sabolek, H., Staley, K.J.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2010
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4167405/
https://ncbi.nlm.nih.gov/pubmed/21076333
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/WNP.0b013e3181fe0709
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