Hydrophobic Substituents of the Phenylmethylsulfamide Moiety Can Be Used for the Development of New Selective Carbonic Anhydrase Inhibitors

A new series of compounds containing a sulfamide moiety as zinc-binding group (ZBG) has been synthesized and tested for determining inhibitory properties against four human carbonic anhydrase (hCA) isoforms, namely, CAs I, II, IX, and XII. The X-ray structure of the cytosolic dominant isoform hCA II...

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Detalhes bibliográficos
Main Authors: De Simone, Giuseppina, Pizika, Ginta, Monti, Simona Maria, Di Fiore, Anna, Ivanova, Jekaterina, Vozny, Igor, Trapencieris, Peteris, Zalubovskis, Raivis, Supuran, Claudiu T., Alterio, Vincenzo
Formato: Artigo
Idioma:Inglês
Publicado em: Hindawi Publishing Corporation 2014
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4167230/
https://ncbi.nlm.nih.gov/pubmed/25258712
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2014/523210
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