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Perturbation of Iron Homeostasis Promotes the Evolution of Antibiotic Resistance
Evolution of antibiotic resistance in microbes is frequently achieved by acquisition of spontaneous mutations during antimicrobial therapy. Here, we demonstrate that inactivation of a central transcriptional regulator of iron homeostasis (Fur) facilitates laboratory evolution of ciprofloxacin resist...
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| Main Authors: | , , , , , , |
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| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
Oxford University Press
2014
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| Teme: | |
| Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4166929/ https://ncbi.nlm.nih.gov/pubmed/25063442 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/molbev/msu223 |
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