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Perturbation of Iron Homeostasis Promotes the Evolution of Antibiotic Resistance
Evolution of antibiotic resistance in microbes is frequently achieved by acquisition of spontaneous mutations during antimicrobial therapy. Here, we demonstrate that inactivation of a central transcriptional regulator of iron homeostasis (Fur) facilitates laboratory evolution of ciprofloxacin resist...
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| 主要な著者: | , , , , , , |
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| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
Oxford University Press
2014
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4166929/ https://ncbi.nlm.nih.gov/pubmed/25063442 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/molbev/msu223 |
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