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Expression of Common Chromosomal Fragile Site Genes, WWOX/FRA16D and FHIT/FRA3B is Downregulated by Exposure to Environmental Carcinogens, UV, and BPDE but not by IR
Common chromosomal fragile sites are unstable genomic loci susceptible to breakage, rearrangement, and are highly recombinogenic. Frequent alterations at these loci in tumor cells led to the hypothesis that they may contribute to cancer development. The two most common chromosomal fragile sites FRA1...
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| Main Authors: | , , , |
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| Format: | Artigo |
| Language: | Inglês |
| Published: |
2005
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4166602/ https://ncbi.nlm.nih.gov/pubmed/16187332 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/mc.20122 |
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