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Expression of Common Chromosomal Fragile Site Genes, WWOX/FRA16D and FHIT/FRA3B is Downregulated by Exposure to Environmental Carcinogens, UV, and BPDE but not by IR

Common chromosomal fragile sites are unstable genomic loci susceptible to breakage, rearrangement, and are highly recombinogenic. Frequent alterations at these loci in tumor cells led to the hypothesis that they may contribute to cancer development. The two most common chromosomal fragile sites FRA1...

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Detalhes bibliográficos
Main Authors: Thavathiru, Elangovan, Ludes-Meyers, John H., MacLeod, Michael C., Aldaz, C. Marcelo
Formato: Artigo
Idioma:Inglês
Publicado em: 2005
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4166602/
https://ncbi.nlm.nih.gov/pubmed/16187332
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/mc.20122
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