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The Senescence-Associated Secretory Phenotype: The Dark Side of Tumor Suppression

Cellular senescence is a tumor-suppressive mechanism that permanently arrests cells at risk for malignant transformation. However, accumulating evidence shows that senescent cells can have deleterious effects on the tissue microenvironment. The most significant of these effects is the acquisition of...

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Detaylı Bibliyografya
Asıl Yazarlar: Coppé, Jean-Philippe, Desprez, Pierre-Yves, Krtolica, Ana, Campisi, Judith
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: 2010
Konular:
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC4166495/
https://ncbi.nlm.nih.gov/pubmed/20078217
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1146/annurev-pathol-121808-102144
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