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PCSK9 and LDLR degradation: regulatory mechanisms in circulation and in cells
PURPOSE OF REVIEW: Proprotein convertase subtilisin/kexin type-9 (PCSK9) binds to LDL receptor (LDLR) and targets it for lysosomal degradation in cells. Decreased hepatic clearance of plasma LDL-cholesterol is the primary gauge of PCSK9 activity in humans; however, PCSK9's evolutionary role may...
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| 第一著者: | |
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| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
Lippincott Williams & Wilkins
2014
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4166010/ https://ncbi.nlm.nih.gov/pubmed/25110901 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/MOL.0000000000000114 |
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