Herpesvirus Protease Inhibition by Dimer Disruption

Kaposi's sarcoma-associated herpesvirus (KSHV), like all herpesviruses, encodes a protease (KSHV Pr), which is necessary for the viral lytic cycle. Herpesvirus proteases function as obligate dimers; however, each monomer has an intact, complete active site which does not interact directly with...

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Autori principali: Shimba, Nobuhisa, Nomura, Anson M., Marnett, Alan B., Craik, Charles S.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Microbiology 2004
Soggetti:
Virus-Cell Interactions
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC416554/
https://ncbi.nlm.nih.gov/pubmed/15163756
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.78.12.6657-6665.2004
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