MethylPurify: tumor purity deconvolution and differential methylation detection from single tumor DNA methylomes

We propose a statistical algorithm MethylPurify that uses regions with bisulfite reads showing discordant methylation levels to infer tumor purity from tumor samples alone. MethylPurify can identify differentially methylated regions (DMRs) from individual tumor methylome samples, without genomic var...

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Bibliographic Details
Main Authors: Zheng, Xiaoqi, Zhao, Qian, Wu, Hua-Jun, Li, Wei, Wang, Haiyun, Meyer, Clifford A, Qin, Qian Alvin, Xu, Han, Zang, Chongzhi, Jiang, Peng, Li, Fuqiang, Hou, Yong, He, Jianxing, Wang, Jun, Zhang, Peng, Zhang, Yong, Liu, Xiaole Shirley
Format: Artigo
Language:Inglês
Published: BioMed Central 2014
Subjects:
Method
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4165374/
https://ncbi.nlm.nih.gov/pubmed/25103624
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13059-014-0419-x
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