MethylPurify: tumor purity deconvolution and differential methylation detection from single tumor DNA methylomes

We propose a statistical algorithm MethylPurify that uses regions with bisulfite reads showing discordant methylation levels to infer tumor purity from tumor samples alone. MethylPurify can identify differentially methylated regions (DMRs) from individual tumor methylome samples, without genomic var...

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Detalhes bibliográficos
Main Authors: Zheng, Xiaoqi, Zhao, Qian, Wu, Hua-Jun, Li, Wei, Wang, Haiyun, Meyer, Clifford A, Qin, Qian Alvin, Xu, Han, Zang, Chongzhi, Jiang, Peng, Li, Fuqiang, Hou, Yong, He, Jianxing, Wang, Jun, Zhang, Peng, Zhang, Yong, Liu, Xiaole Shirley
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2014
Assuntos:
Method
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4165374/
https://ncbi.nlm.nih.gov/pubmed/25103624
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13059-014-0419-x
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