MethylPurify: tumor purity deconvolution and differential methylation detection from single tumor DNA methylomes

We propose a statistical algorithm MethylPurify that uses regions with bisulfite reads showing discordant methylation levels to infer tumor purity from tumor samples alone. MethylPurify can identify differentially methylated regions (DMRs) from individual tumor methylome samples, without genomic var...

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Detalles Bibliográficos
Main Authors: Zheng, Xiaoqi, Zhao, Qian, Wu, Hua-Jun, Li, Wei, Wang, Haiyun, Meyer, Clifford A, Qin, Qian Alvin, Xu, Han, Zang, Chongzhi, Jiang, Peng, Li, Fuqiang, Hou, Yong, He, Jianxing, Wang, Jun, Zhang, Peng, Zhang, Yong, Liu, Xiaole Shirley
Formato: Artigo
Idioma:Inglês
Publicado: BioMed Central 2014
Assuntos:
Method
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4165374/
https://ncbi.nlm.nih.gov/pubmed/25103624
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13059-014-0419-x
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