MethylPurify: tumor purity deconvolution and differential methylation detection from single tumor DNA methylomes

We propose a statistical algorithm MethylPurify that uses regions with bisulfite reads showing discordant methylation levels to infer tumor purity from tumor samples alone. MethylPurify can identify differentially methylated regions (DMRs) from individual tumor methylome samples, without genomic var...

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Bibliografski detalji
Glavni autori: Zheng, Xiaoqi, Zhao, Qian, Wu, Hua-Jun, Li, Wei, Wang, Haiyun, Meyer, Clifford A, Qin, Qian Alvin, Xu, Han, Zang, Chongzhi, Jiang, Peng, Li, Fuqiang, Hou, Yong, He, Jianxing, Wang, Jun, Zhang, Peng, Zhang, Yong, Liu, Xiaole Shirley
Format: Artigo
Jezik:Inglês
Izdano: BioMed Central 2014
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Method
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4165374/
https://ncbi.nlm.nih.gov/pubmed/25103624
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13059-014-0419-x
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