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Direct Binding of Hepatitis C Virus Core to gC1qR on CD4(+) and CD8(+) T Cells Leads to Impaired Activation of Lck and Akt

Complement plays a pivotal role in the regulation of innate and adaptive immunity. It has been shown that the binding of C1q, a natural ligand of gC1qR, on T cells inhibits their proliferation. Here, we demonstrate that direct binding of the hepatitis C virus (HCV) core to gC1qR on T cells leads to...

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書誌詳細
主要な著者: Yao, Zhi Qiang, Eisen-Vandervelde, Audrey, Waggoner, Stephen N., Cale, Evan M., Hahn, Young S.
フォーマット: Artigo
言語:Inglês
出版事項: American Society for Microbiology 2004
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC416530/
https://ncbi.nlm.nih.gov/pubmed/15163734
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.78.12.6409-6419.2004
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