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Direct Binding of Hepatitis C Virus Core to gC1qR on CD4(+) and CD8(+) T Cells Leads to Impaired Activation of Lck and Akt
Complement plays a pivotal role in the regulation of innate and adaptive immunity. It has been shown that the binding of C1q, a natural ligand of gC1qR, on T cells inhibits their proliferation. Here, we demonstrate that direct binding of the hepatitis C virus (HCV) core to gC1qR on T cells leads to...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society for Microbiology
2004
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC416530/ https://ncbi.nlm.nih.gov/pubmed/15163734 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.78.12.6409-6419.2004 |
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