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Relationship between Cerebral Sigma-1 Receptor Occupancy and Attenuation of Cocaine’s Motor Stimulatory Effects in Mice by PD144418
Psychostimulant effects of cocaine are mediated partly by agonist actions at sigma-1 (σ(1)) receptors. Selective σ(1) receptor antagonists attenuate these effects and provide a potential avenue for pharmacotherapy. However, the selective and high affinity σ(1) antagonist PD144418 (1,2,3,6-tetrahydro...
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| Main Authors: | , , , , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
The American Society for Pharmacology and Experimental Therapeutics
2014
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4165029/ https://ncbi.nlm.nih.gov/pubmed/25100754 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/jpet.114.216671 |
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