Mice With Hepatocyte-Specific Deficiency of Type 3 Deiodinase Have Intact Liver Regeneration and Accelerated Recovery From Nonthyroidal Illness After Toxin-Induced Hepatonecrosis

Type 3 deiodinase (D3), the physiologic inactivator of thyroid hormones, is induced during tissue injury and regeneration. This has led to the hypotheses that D3 impacts injury tolerance by reducing local T3 signaling and contributes to the fall in serum triiodothyronine (T3) observed in up to 75% o...

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Main Authors: Castroneves, Luciana A., Jugo, Rebecca H., Maynard, Michelle A., Lee, Jennifer S., Wassner, Ari J., Dorfman, David, Bronson, Roderick T., Ukomadu, Chinweike, Agoston, Agoston T., Ding, Lai, Luongo, Cristina, Guo, Cuicui, Song, Huaidong, Demchev, Valeriy, Lee, Nicholas Y., Feldman, Henry A., Vella, Kristen R., Peake, Roy W., Hartigan, Christina, Kellogg, Mark D., Desai, Anal, Salvatore, Domenico, Dentice, Monica, Huang, Stephen A.
Format: Artigo
Jezik:Inglês
Izdano: Endocrine Society 2014
Teme:
Thyroid-TRH-TSH
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4164928/
https://ncbi.nlm.nih.gov/pubmed/25004090
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/en.2013-2028
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