ABCB1 regulation through LRPPRC is influenced by the methylation status of the GC -100 box in its promoter

One of the potential mechanisms of imatinib mesylate (IM) resistance in chronic myeloid leukemia (CML) is increased level of P-glycoprotein (Pgp). Pgp is an efflux pump capable of activating the multidrug resistance (MDR) phenotype. The gene encoding Pgp (ABCB1) has several binding sites in its prom...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Corrêa, Stephany, Binato, Renata, Du Rocher, Bárbara, Ferreira, Gerson, Cappelletti, Paola, Soares-Lima, Sheila, Pinto, Luis Felipe, Mencalha, André, Abdelhay, Eliana
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Landes Bioscience 2014
Pynciau:
Research Paper
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC4164502/
https://ncbi.nlm.nih.gov/pubmed/25089713
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/epi.29675
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