ABCB1 regulation through LRPPRC is influenced by the methylation status of the GC -100 box in its promoter

One of the potential mechanisms of imatinib mesylate (IM) resistance in chronic myeloid leukemia (CML) is increased level of P-glycoprotein (Pgp). Pgp is an efflux pump capable of activating the multidrug resistance (MDR) phenotype. The gene encoding Pgp (ABCB1) has several binding sites in its prom...

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Bibliographische Detailangaben
Hauptverfasser: Corrêa, Stephany, Binato, Renata, Du Rocher, Bárbara, Ferreira, Gerson, Cappelletti, Paola, Soares-Lima, Sheila, Pinto, Luis Felipe, Mencalha, André, Abdelhay, Eliana
Format: Artigo
Sprache:Inglês
Veröffentlicht: Landes Bioscience 2014
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Research Paper
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4164502/
https://ncbi.nlm.nih.gov/pubmed/25089713
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/epi.29675
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