Functional DNA methylation in a transcript specific 3′UTR region of TrkB associates with suicide

Previous studies indicate that a subgroup of suicide completers has low cortical brain expression levels of TrkB-T1, a TrkB gene transcript that is highly expressed in astrocytes. Epigenetic modifications, including methylation changes in the TrkB promoter, partially explain TrkB-T1 low expression l...

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Hlavní autoři: Maussion, Gilles, Yang, Jennie, Suderman, Matthew, Diallo, Alpha, Nagy, Corina, Arnovitz, Mitchell, Mechawar, Naguib, Turecki, Gustavo
Médium: Artigo
Jazyk:Inglês
Vydáno: Landes Bioscience 2014
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Research Paper
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4164491/
https://ncbi.nlm.nih.gov/pubmed/24802768
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/epi.29068
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