Regulation of a Truncated Form of Tropomyosin-Related Kinase B (TrkB) by Hsa-miR-185* in Frontal Cortex of Suicide Completers

BACKGROUND: TrkB-T1 is a BDNF receptor lacking a tyrosine kinase domain that is highly expressed in astrocytes and regulates BDNF-evoked calcium transients. Previous studies indicate that downregulation of TrkB-T1 in frontal cortex may be involved in neurobiological processes underlying suicide. MET...

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Detalhes bibliográficos
Main Authors: Maussion, Gilles, Yang, Jennie, Yerko, Volodymyr, Barker, Philip, Mechawar, Naguib, Ernst, Carl, Turecki, Gustavo
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2012
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3382618/
https://ncbi.nlm.nih.gov/pubmed/22802923
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0039301
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