Identification of a Distinctive Mutation Spectrum Associated with High Levels of Transcription in Yeast

High levels of transcription are associated with increased mutation rates in Saccharomyces cerevisiae, a phenomenon termed transcription-associated mutation (TAM). To obtain insight into the mechanism of TAM, we obtained LYS2 forward mutation spectra under low- versus high-transcription conditions i...

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Main Authors: Lippert, Malcolm J., Freedman, Jennifer A., Barber, Melissa A., Jinks-Robertson, Sue
Format: Artigo
Jezik:Inglês
Izdano: American Society for Microbiology 2004
Teme:
DNA Dynamics and Chromosome Structure
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC416428/
https://ncbi.nlm.nih.gov/pubmed/15143174
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.24.11.4801-4809.2004
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