Mutations in the SAM Domain of the ETV6-NTRK3 Chimeric Tyrosine Kinase Block Polymerization and Transformation Activity

The 12p13 ETV6 (TEL) gene is frequently targeted by chromosomal translocations in human malignancies, resulting in the formation of oncogenic ETV6 gene fusions. Many of the known partner genes encode protein tyrosine kinases (PTKs), generating fusion proteins that function as chimeric PTKs. ETV6-NTR...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Main Authors: Tognon, Cristina E., Mackereth, Cameron D., Somasiri, Aruna M., McIntosh, Lawrence P., Sorensen, Poul H. B.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2004
Assuntos:
Cell Growth and Development
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC416412/
https://ncbi.nlm.nih.gov/pubmed/15143160
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.24.11.4636-4650.2004
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados