Mutations in the SAM Domain of the ETV6-NTRK3 Chimeric Tyrosine Kinase Block Polymerization and Transformation Activity

The 12p13 ETV6 (TEL) gene is frequently targeted by chromosomal translocations in human malignancies, resulting in the formation of oncogenic ETV6 gene fusions. Many of the known partner genes encode protein tyrosine kinases (PTKs), generating fusion proteins that function as chimeric PTKs. ETV6-NTR...

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Bibliographic Details
Main Authors: Tognon, Cristina E., Mackereth, Cameron D., Somasiri, Aruna M., McIntosh, Lawrence P., Sorensen, Poul H. B.
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2004
Subjects:
Cell Growth and Development
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC416412/
https://ncbi.nlm.nih.gov/pubmed/15143160
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.24.11.4636-4650.2004
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