Broadly Neutralizing Antibodies and Viral inducers decrease rebound from HIV-1 latent reservoirs in humanized mice

Latent reservoirs of HIV-1 infected cells are refractory to antiretroviral therapies (ART) and remain the major barrier to curing HIV-1. Because latently infected cells are long-lived, immunologically invisible, and may undergo homeostatic proliferation, a “shock and kill” approach has been proposed...

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Main Authors: Halper-Stromberg, Ariel, Lu, Ching-Lan, Klein, Florian, Horwitz, Joshua A., Bournazos, Stylianos, Nogueira, Lillian, Eisenreich, Thomas R., Liu, Cassie, Gazumyan, Anna, Schaefer, Uwe, Furze, Rebecca C., Seaman, Michael S., Prinjha, Rab, Tarakhovsky, Alexander, Ravetch, Jeffrey V., Nussenzweig, Michel C.
Format: Artigo
Language:Inglês
Published: 2014
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4163911/
https://ncbi.nlm.nih.gov/pubmed/25131989
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2014.07.043
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