Ribosomal protein S27-like is a physiological regulator of p53 that suppresses genomic instability and tumorigenesis

Cell-based studies showed that several Mdm2-binding ribosomal proteins, upon overexpression, stabilize and activate p53. In contrast, here we show in a mouse knockout study that Mdm2-binding ribosomal protein S27-like (Rps27l), upon disruption, activates p53. Germline inactivation of Rps27l triggers...

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Main Authors: Xiong, Xiufang, Zhao, Yongchao, Tang, Fei, Wei, Dongping, Thomas, Daffyd, Wang, Xiang, Liu, Yang, Zheng, Pan, Sun, Yi
Formáid: Artigo
Teanga:Inglês
Foilsithe: eLife Sciences Publications, Ltd 2014
Ábhair:
Cell Biology
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4163686/
https://ncbi.nlm.nih.gov/pubmed/25144937
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.02236
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