Targeting mTORC1-mediated Metabolic Addiction Overcomes Fludarabine Resistance in Malignant B Cells

mTORC1 activation occurs frequently in cancers, yet clinical efficacy of rapalogs is limited due to the associated activation of upstream survival pathways. An alternative approach is to inhibit downstream of mTORC1; therefore, acquired resistance to fludarabine (Flu), a purine analog and anti-metab...

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Bibliographic Details
Main Authors: Sharma, Arishya, Janocha, Allison J., Hill, Brian T., Smith, Mitchell R., Erzurum, Serpil C., Almasan, Alexandru
Format: Artigo
Language:Inglês
Published: 2014
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4163513/
https://ncbi.nlm.nih.gov/pubmed/25061101
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1541-7786.MCR-14-0124
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