Mechanistic basis for functional promiscuity in the TNF and TNF Receptor Superfamilies: Structure of the LIGHT:DcR3 Assembly

LIGHT initiates intracellular signaling via engagement of the two TNF receptors, HVEM and LTβR. In humans, LIGHT is neutralized by DcR3, a unique soluble member of the TNFR superfamily, which tightly binds LIGHT and inhibits its interactions with HVEM and LTβR. DcR3 also neutralizes two other TNF li...

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Main Authors: Liu, Weifeng, Zhan, Chenyang, Cheng, Huiyong, Kumar, P. Rajesh, Bonanno, Jeffrey B., Nathenson, Stanley G., Almo, Steven C.
格式: Artigo
語言:Inglês
出版: 2014
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Article
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC4163024/
https://ncbi.nlm.nih.gov/pubmed/25087510
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.str.2014.06.013
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