An integrated analysis of the SOX2 microRNA response program in human pluripotent and nullipotent stem cell lines

BACKGROUND: SOX2 is a core component of the transcriptional network responsible for maintaining embryonal carcinoma cells (ECCs) in a pluripotent, undifferentiated state of self-renewal. As such, SOX2 is an oncogenic transcription factor and crucial cancer stem cell (CSC) biomarker in embryonal carc...

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Main Authors: Vencken, Sebastian F, Sethupathy, Praveen, Blackshields, Gordon, Spillane, Cathy, Elbaruni, Salah, Sheils, Orla, Gallagher, Michael F, O’Leary, John J
Format: Artigo
Jezik:Inglês
Izdano: BioMed Central 2014
Teme:
Research Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4162954/
https://ncbi.nlm.nih.gov/pubmed/25156079
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2164-15-711
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