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Targeting the C-terminal focal adhesion kinase scaffold in pancreatic cancer
Preliminary studies in our laboratory have demonstrated the importance of both the NH2 and COOH terminus scaffolding functions of focal adhesion kinase (FAK). Here, we describe a new small molecule inhibitor, C10 that targets the FAK C-terminus scaffold. C10 showed marked selectivity for cells overe...
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| Main Authors: | , , , , , , , |
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| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
2014
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| Teme: | |
| Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4162749/ https://ncbi.nlm.nih.gov/pubmed/25067788 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.canlet.2014.07.032 |
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