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Presenilin modulates EGFR signaling and cell transformation by regulating the ubiquitin ligase Fbw7
The epidermal growth factor receptor (EGFR) and Notch signaling pathways have antagonistic roles during epidermal differentiation and carcinogenesis. The molecular mechanisms regulating the crosstalk between EGFR and Notch during epidermal transformation are largely unknown. We found enhanced EGFR-d...
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| Hauptverfasser: | , , , , , , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
2010
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4162408/ https://ncbi.nlm.nih.gov/pubmed/20208556 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/onc.2010.57 |
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