Structure-Based Discovery of Natural Product-Like TNF-α Inhibitors

[Image: see text] Two natural product-like inhibitors of TNF-α have been identified using structure-based virtual screening. These compounds represent only the third and fourth examples of direct target of TNF-α by a small molecule and display comparable potency to the strongest TNF-α inhibitor repo...

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Hlavní autoři: Chan, Daniel Shiu-Hin, Lee, Ho-Man, Yang, Fang, Che, Chi-Ming, Wong, Catherine C. L., Abagyan, Ruben, Leung, Chung-Hang, Ma, Dik-Lung
Médium: Artigo
Jazyk:Inglês
Vydáno: 2010
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4162403/
https://ncbi.nlm.nih.gov/pubmed/20235259
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/anie.200907360
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