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Discovery of a Natural Product-Like c-myc G-Quadruplex DNA Groove-Binder by Molecular Docking
The natural product-like carbamide (1) has been identified as a stabilizer of the c-myc G-quadruplex through high-throughput virtual screening. NMR and molecular modeling experiments revealed a groove-binding mode for 1. The biological activity of 1 against the c-myc G-quadruplex was confirmed by it...
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| Autors principals: | , , , , , , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
Public Library of Science
2012
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3422278/ https://ncbi.nlm.nih.gov/pubmed/22912844 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0043278 |
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