Discovery of a Natural Product-Like c-myc G-Quadruplex DNA Groove-Binder by Molecular Docking

The natural product-like carbamide (1) has been identified as a stabilizer of the c-myc G-quadruplex through high-throughput virtual screening. NMR and molecular modeling experiments revealed a groove-binding mode for 1. The biological activity of 1 against the c-myc G-quadruplex was confirmed by it...

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Main Authors: Ma, Dik-Lung, Chan, Daniel Shiu-Hin, Fu, Wai-Chung, He, Hong-Zhang, Yang, Hui, Yan, Siu-Cheong, Leung, Chung-Hang
格式: Artigo
語言:Inglês
出版: Public Library of Science 2012
主題:
Research Article
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC3422278/
https://ncbi.nlm.nih.gov/pubmed/22912844
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0043278
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