Silencing of the glycerophosphocholine phosphodiesterase GDPD5 alters the phospholipid metabolite profile in a breast cancer model in vivo as monitored by (31)P Magnetic Resonance Spectroscopy

Abnormal choline phospholipid metabolism is an emerging hallmark of cancer, which is implicated in carcinogenesis and tumor progression. The malignant metabolic phenotype is characterized by high levels of phosphocholine (PC) and relatively low levels of glycerophosphocholine (GPC) in aggressive bre...

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Autors principals: Wijnen, J.P., Jiang, L., Greenwood, T.R., Cheng, M., Döpkens, M., Cao, M.D., Bhujwalla, Z.M., Krishnamachary, B., Klomp, D.W.J., Glunde, K.
Format: Artigo
Idioma:Inglês
Publicat: 2014
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4162314/
https://ncbi.nlm.nih.gov/pubmed/24764256
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/nbm.3106
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