Coronavirus Nsp10, a Critical Co-factor for Activation of Multiple Replicative Enzymes

The RNA-synthesizing machinery of the severe acute respiratory syndrome Coronavirus (SARS-CoV) is composed of 16 non-structural proteins (nsp1–16) encoded by ORF1a/1b. The 148-amino acid nsp10 subunit contains two zinc fingers and is known to interact with both nsp14 and nsp16, stimulating their res...

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Hauptverfasser: Bouvet, Mickaël, Lugari, Adrien, Posthuma, Clara C., Zevenhoven, Jessika C., Bernard, Stéphanie, Betzi, Stéphane, Imbert, Isabelle, Canard, Bruno, Guillemot, Jean-Claude, Lécine, Patrick, Pfefferle, Susanne, Drosten, Christian, Snijder, Eric J., Decroly, Etienne, Morelli, Xavier
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Biochemistry and Molecular Biology 2014
Schlagworte:
Microbiology
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4162180/
https://ncbi.nlm.nih.gov/pubmed/25074927
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.577353
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